| Year |
Round |
Pick |
Team |
Player |
Previous Team |
| 2008 | 1 | 1 | Kansas City Wizards | Chance Myers | UCLA |
| 2008 | 1 | 2 | FC Dallas | Brek Shea | Generation Adidas |
| 2008 | 1 | 3 | Real Salt Lake | Tony Beltran | UCLA |
| 2008 | 1 | 4 | Los Angeles Galaxy | Sean Franklin | Cal State Northridge |
| 2008 | 1 | 5 | Colorado Rapids | Ciaran O'Brien | UC Santa Barbara |
| 2008 | 1 | 6 | Columbus Crew | Andy Iro | UC Santa Barbara |
| 2008 | 1 | 7 | Chicago Fire | Patrick Nyarko | Virginia Tech |
| 2008 | 1 | 8 | FC Dallas | Josh Lambo | Generation Adidas |
| 2008 | 1 | 9 | Toronto FC | Julius James | University of Connecticut |
| 2008 | 1 | 10 | Toronto FC | Pat Phelan | Wake Forest University |
| 2008 | 1 | 11 | Kansas City Wizards | Rogers Espinoza | Ohio State University |
| 2008 | 1 | 12 | Chicago Fire | Dominic Cervi | Tulsa |
| 2008 | 1 | 13 | New England Revolution | Rob Valentino | University of San Francisco |
| 2008 | 1 | 14 | Real Salt Lake | David Horst | Old Dominion University |
| |
2008 | 2 | 15 | San Jose Earthquakes | Shea Salinas | Furman University | | 2008 | 2 | 16 | New York Red Bull | Eric Brunner | Ohio State University |
| 2008 | 2 | 17 | Real Salt Lake | Alex Nimo | Generation Adidas |
| 2008 | 2 | 18 | New England Revolution | Michael Videira | Duke University |
| 2008 | 2 | 19 | FC Dallas | Eric Avila | UC Santa Barbara |
| 2008 | 2 | 20 | Columbus Crew | George Josten | Gonzaga University |
| 2008 | 2 | 21 | Los Angeles Galaxy | Ely Allen | University of Washington |
| 2008 | 2 | 22 | Columbus Crew | Ricardo Pierre-Louis | Lee University |
| 2008 | 2 | 23 | Kansas City Wizards | Yomby William | Old Dominion University |
| 2008 | 2 | 24 | D.C. United | Andrew Jacobson | UC Berkeley |
| 2008 | 2 | 25 | Kansas City Wizards | Jonathan Leathers | Furman University |
| 2008 | 2 | 26 | Chicago Fire | Peter Lowry | Santa Clara University |
| 2008 | 2 | 27 | New England Revolution | Joe Germanese | Duke University |
| 2008 | 2 | 28 | Toronto FC | Brian Edwards | Wake Forest University |
| |
2008 | 3 | 29 | Los Angeles Galaxy | Julian Valentin | Wake Forest University | | 2008 | 3 | 30 | Toronto FC | Mike Zaher | UCLA |
| 2008 | 3 | 31 | Columbus Crew | Ryan Miller | University of Notre Dame |
| 2008 | 3 | 32 | New York Red Bull | Luke Sassano | UC Berkeley |
| 2008 | 3 | 33 | D.C. United | Ryan Cordeiro | University of Connecticut |
| 2008 | 3 | 34 | Los Angeles Galaxy | Matt Allen | Creighton University |
| 2008 | 3 | 35 | Toronto FC | Joseph Lapira | University of Notre Dame |
| 2008 | 3 | 36 | Colorado Rapids | Adrian Chevannes | Southern Methodist University |
| 2008 | 3 | 37 | Real Salt Lake | Brennan Tennelle | UC Santa Barbara |
| 2008 | 3 | 38 | Chicago Fire | Dwight Barnett | Lynn University |
| 2008 | 3 | 39 | Kansas City Wizards | Matt Marquess | Santa Clara University |
| 2008 | 3 | 40 | Chicago Fire | Stephen King | University of Maryland |
| 2008 | 3 | 41 | New England Revolution | Matt Britner | Brown University |
| 2008 | 3 | 42 | Houston Dynamo | Geoff Cameron | University of Rhode Island |
| |
2008 | 4 | 43 | Chivas USA | Keith Savage | University of West Florida | | 2008 | 4 | 44 | New York Red Bull | David Roth | Northwestern University |
| 2008 | 4 | 45 | FC Dallas | Jamil Roberts | Santa Clara University |
| 2008 | 4 | 46 | Los Angeles Galaxy | Brandon McDonald | University of San Francisco |
| 2008 | 4 | 47 | Colorado Rapids | Brian Grazier | Saint Louis University |
| 2008 | 4 | 48 | Columbus Crew | Steven Lenhart | Azusa Pacific University |
| 2008 | 4 | 49 | Colorado Rapids | Scott Campbell | University of North Carolina at Chapel Hill |
| 2008 | 4 | 50 | FC Dallas | Ben Nason | Virginia Tech |
| 2008 | 4 | 51 | Los Angeles Galaxy | Matt Hatzke | Santa Clara University |
| 2008 | 4 | 52 | D.C. United | Tony Schmitz | Creighton University |
| 2008 | 4 | 53 | Kansas City Wizards | Rauwshan McKenzie | Michigan State University |
| 2008 | 4 | 54 | Chicago Fire | Austin Washington | Gonzaga University |
| 2008 | 4 | 55 | New England Revolution | Spencer Wadsworth | Duke University |
| 2008 | 4 | 56 | Houston Dynamo | Jeremy Barlow | University of Virginia |
